Identification of Embryonic Chicken Proteases Activating Newcastle Disease Virus and Their Roles in the Pathogenicity of Virus Used as <i>In Ovo</i> Vaccine-Reference-Cited by-同舟云学术

Identification of Embryonic Chicken Proteases Activating Newcastle Disease Virus and Their Roles in the Pathogenicity of Virus Used as In Ovo Vaccine

Published:2023-05-31 Issue:5 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Feng Helong¹²,Yao Lun¹³⁴,Zeng Zhe¹³⁴,Jiang Liren¹³⁴,Shang Yu¹³⁴,Wang Hongcai¹³⁴,Li Li¹³⁴,Wang Zichen¹³⁴,Wang Xin¹³⁴,Yang Hongchun¹³⁴,Zhao Qingqing¹³⁴,Ren Xiangfei¹³⁴,Zhang Tengfei¹³⁴^ORCID,Zhang Rongrong¹³⁴,Guo Yunqing¹³⁴,Lu Qin¹³⁴,Hu Qiao¹³⁴,Zhang Wenting¹³⁴,Ding Chan⁵^ORCID,Shao Huabin¹³⁴,Cheng Guofu²,Luo Qingping¹³⁴⁶,Wen Guoyuan¹³⁴⁶^ORCID

Affiliation:

1. Institute of Animal Husbandry and Veterinary Sciences, Hubei Academy of Agricultural Sciences, Wuhan, China

2. Division of Veterinary Pathology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China

3. Key Laboratory of Prevention and Control Agents for Animal Bacteriosis, Ministry of Agriculture, Wuhan, China

4. Hubei Provincial Key Laboratory of Animal Pathogenic Microbiology, Wuhan, China

5. Department of Avian Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China

6. Hubei Hongshan Laboratory, Wuhan, China

Abstract

As an attractive immunization approach for chickens, in ovo vaccination can induce a considerable degree of protection by the time of hatching, provide support in closing the window in which birds are susceptible to infection, facilitate fast and uniform vaccine delivery, and reduce labor costs by the use of mechanized injectors. The commercial live Newcastle disease virus (NDV) vaccine strains are not safe for in ovo vaccination and cause the death of chicken embryos.

Funder

National Natural Science Foundation of China

Industrial chain Fund of Hongshan Laboratory

The earmarked fund for CARS-41

The Central Public Interest Scientific Institution Basal Research Fund

MOE | Fundamental Research Funds for the Central Universities

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00324-23

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