Combinational Deletions of MGF360-9L and MGF505-7R Attenuated Highly Virulent African Swine Fever Virus and Conferred Protection against Homologous Challenge-Reference-Cited by-同舟云学术

Combinational Deletions of MGF360-9L and MGF505-7R Attenuated Highly Virulent African Swine Fever Virus and Conferred Protection against Homologous Challenge

Published:2022-07-27 Issue:14 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Ding Mingyang¹²³⁴,Dang Wen²³⁴,Liu Huanan²³⁴,Xu Fan²³⁴,Huang Huaguo²³⁴⁵,Sunkang Yongjie²³⁴,Li Tao²³⁴,Pei Jingjing²³⁴,Liu Xiangtao²³⁴,Zhang Yong¹,Zheng Haixue²³⁴^ORCID

Affiliation:

1. College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China

2. State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

3. National Foot and Mouth Diseases Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

4. Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

5. College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China

Abstract

Currently, the deficiency in commercially available vaccines or therapeutic options against African swine fever constitutes a matter of major concern in the swine industry globally. Here, we report the design and construction of a recombinant ASFV mutant harboring combinational deletions of interferon inhibitors MGF360-9L and MGF505-7R based on a genotype II ASFV CN/GS/2018 strain currently circulating in China.

Funder

Key-Area Research and Development Program of Guangdong Province

National Key R&D Program of China

Chinese Academy of Agricultural Science and Technology Innovation Program

Technology Major Projects of Gansu Province

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00329-22

Reference41 articles.