Butyrate Reprograms Expression of Specific Interferon-Stimulated Genes

Author:

Chemudupati Mahesh12,Kenney Adam D.12,Smith Anna C.132,Fillinger Robert J.124,Zhang Lizhi12,Zani Ashley12,Liu Shan-Lu1324,Anderson Matthew Z.124ORCID,Sharma Amit132,Yount Jacob S.124

Affiliation:

1. Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA

2. Infectious Diseases Institute, The Ohio State University, Columbus, Ohio, USA

3. Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA

4. Department of Microbiology, The Ohio State University, Columbus, Ohio, USA

Abstract

Butyrate is a lipid produced by intestinal bacteria. Here, we newly show that butyrate reprograms the innate antiviral immune response mediated by type I interferons (IFNs). Many of the antiviral genes induced by type I IFNs are repressed in the presence of butyrate, resulting in increased virus infection and replication. Our research demonstrates that metabolites produced by the gut microbiome, such as butyrate, can have complex effects on cellular physiology, including dampening of an inflammatory innate immune pathway resulting in a proviral cellular environment. Our work further suggests that butyrate could be broadly used as a tool to increase growth of virus stocks for research and for the generation of vaccines.

Funder

HHS | National Institutes of Health

National Science Foundation

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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