Marek’s Disease Virus Virulence Genes Encode Circular RNAs

Author:

Chasseur Alexis S.1,Trozzi Gabrielle1,Istasse Céline1,Petit Astrid1,Rasschaert Perrine2,Denesvre Caroline3ORCID,Kaufer Benedikt B.45,Bertzbach Luca D.4ORCID,Muylkens Benoît1ORCID,Coupeau Damien1

Affiliation:

1. Namur Research Institute for Life Sciences (NARILIS), Integrated Veterinary Research Unit (URVI), University of Namur, Namur, Belgium

2. Equipe Transcription et Lymphome Viro-Induit (TLVI), UMR 7261 CNRS, UFR Sciences et Techniques, Université François Rabelais de Tours, Parc de Grandmont, Tours, France

3. INRAE, UMR1282 ISP, Equipe Biologie des Virus Aviaires, Nouzilly, France

4. Institute of Virology, Freie Universität Berlin, Berlin, Germany

5. Veterinary Centre for Resistance Research (TZR), Freie Universität Berlin, Berlin, Germany

Abstract

Circular RNAs (circRNAs) were rediscovered in recent years both in physiological and pathological contexts, such as in cancer. Viral circRNAs are encoded by at least two human herpesviruses, the Epstein Barr virus and the Kaposi’s Sarcoma-associated herpesvirus, both associated with the development of lymphoma.

Funder

FNRS | Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture

Fonds Spécial de la Recherche

Volkswagen Foundation

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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