Author:
Luo Guanpingsheng,Gebremariam Teclegiorgis,Lee Hongkyu,Edwards John E.,Kovanda Laura,Ibrahim Ashraf S.
Abstract
ABSTRACTWe studied thein vitroandin vivoefficacies of the investigational drug isavuconazole against mucormycosis due toRhizopus delemar. Isavuconazole was effective, with MIC and minimal fungicidal concentration (MFC) values ranging between 0.125 and 1.00 μg/ml. A high dose of isavuconazole prolonged the survival time and lowered the tissue fungal burden of cyclophosphamide/cortisone acetate-treated mice infected withR. delemarand was as effective as a high-dose liposomal amphotericin B treatment. These results support the further development of this azole against mucormycosis.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
66 articles.
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