Affiliation:
1. Biocatalysis Research Group, College of Pharmacy, University of Iowa, Iowa City 52242.
Abstract
Aspergillus alliaceus UI 315 was examined for its ability to metabolize 3-methoxy-17 beta-estradiol. Preparative-scale incubations with this substrate afforded good yields of 6 beta-hydroxy-17 beta-estradiol, 4-hydroxy-17 beta-estradiol, and 4,6 beta-dihydroxy-17 beta-estradiol, which were identified by high-pressure liquid chromatography, 1H and 13C nuclear magnetic resonance, and high-resolution mass spectrometry.
Publisher
American Society for Microbiology
Subject
Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology
Reference18 articles.
1. Catechol estrogens (2- and 4-hydroxy-estrogens): chemistry, biogenesis, metabolism, occurrence and physiological significance;Ball P.;Acta Endocrinol.,1980
2. Microbial transformation of natural antitumor compounds. 1. Conversion of acronycine to 9-hydroxyacronycine by Cunninghamella echinulata;Betts R. B.;J. Med. Chem.,1974
3. Charney W. and H. L. Herzog. 1967. Microbial transformations of steroids. Academic Press Inc. New York.
4. Stereochemistry of rings A & B in 6-substituted A4-3-oxo-steroids-1H allylic spin-spin coupling in rigid systems;Collins D. J.;Tetrahedron Lett.,1963
5. Steroids. CCLXI. Microbiological hydroxylation of estrone derivatives with Fusarium moniliforma;Crabbe P.;J. Org. Chem.,1964
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献