Epstein-Barr Virus Genomes Reveal Population Structure and Type 1 Association with Endemic Burkitt Lymphoma-Reference-Cited by-同舟云学术

Epstein-Barr Virus Genomes Reveal Population Structure and Type 1 Association with Endemic Burkitt Lymphoma

Published:2020-08-17 Issue:17 Volume:94 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Kaymaz Yasin¹^ORCID,Oduor Cliff I.²³,Aydemir Ozkan³,Luftig Micah A.⁴⁵^ORCID,Otieno Juliana A.⁶,Ong’echa John Michael²,Bailey Jeffrey A.³,Moormann Ann M.⁷^ORCID

Affiliation:

1. Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

2. Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya

3. Department of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA

4. Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA

5. Center for Virology, Duke University School of Medicine, Durham, North Carolina, USA

6. Jaramogi Oginga Odinga Teaching and Referral Hospital, Ministry of Health, Kisumu, Kenya

7. Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA

Abstract

Improved viral enrichment methods conclusively demonstrate EBV type 1 to be more prevalent in eBL patients than in geographically matched healthy controls, which previously underrepresented the prevalence of EBV type 2. Genome-wide association analysis between cases and controls identifies six eBL-associated nonsynonymous variants in EBNA1, EBNA2, BcLF1, and BARF1 genes. Analysis of population structure reveals that EBV type 2 exists as two genomic subgroups and was more commonly found in female than in male eBL patients.

Funder

UMCCTS Pilot Project Program

Turkish Ministry of Education Graduate Study Abroad Program

HHS | NIH | National Cancer Institute

HHS | National Institutes of Health

Thrasher Research Fund

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02007-19