Contribution of Laccase Expression to Immune Response against Cryptococcus gattii Infection-Reference-Cited by-同舟云学术

Contribution of Laccase Expression to Immune Response against Cryptococcus gattii Infection

Published:2020-02-20 Issue:3 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Hansakon Adithap¹²,Ngamskulrungroj Popchai³,Angkasekwinai Pornpimon¹

Affiliation:

1. Department of Medical Technology, Faculty of Allied Health Sciences, Thammasat University, Bangkok, Thailand

2. Graduate Program in Biomedical Science, Faculty of Allied Health Sciences, Thammasat University, Bangkok, Thailand

3. Department of Microbiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand

Abstract

Cryptococcosis is an infectious disease caused by two fungal species, Cryptococcus neoformans and Cryptococcus gattii . While C. neoformans affects mainly immunocompromised patients, C. gattii infects both immunocompetent and immunocompromised individuals. Laccase is an important virulence factor that contributes to the virulence of C. neoformans by promoting pulmonary growth and dissemination to the brain. The presence of laccase in C. neoformans can shift the host immune response toward a nonprotective Th2-type response.

Funder

Thammasat University

Royal Golden Jubilee (RGJ) Ph.D. Programme

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00712-19

Reference44 articles.

1. Cryptococcosis

2. Cryptococcus: from environmental saprophyte to global pathogen