Bile Salts Differentially Enhance Resistance of Enterohemorrhagic Escherichia coli O157:H7 to Host Defense Peptides

Author:

Gadishaw-Lue Crystal1,Banaag Alyssa1,Birstonas Sarah1,Francis Aju-Sue1,Barnett Foster Debora12

Affiliation:

1. Department of Chemistry and Biology, Ryerson University, Toronto, Ontario, Canada

2. Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada

Abstract

During passage through the human gastrointestinal tract, enterohemorrhagic Escherichia coli (EHEC) is exposed to membrane-damaging bile in the small intestine. We previously reported that EHEC treatment with a physiological bile salt mixture upregulates basRS , encoding a two-component system, and arnBCADTEF , encoding the aminoarabinose lipid A modification pathway (J.

Funder

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference51 articles.

1. Karpman D, Ståhl A. 2014. Enterohemorrhagic Escherichia coli pathogenesis and the host response, p 403–417. In Sperandio V, Hovde CJ (ed), Enterohemorrhagic Escherichia coli and other Shiga toxin-producing E. coli. ASM Press, Washington, DC.

2. Enterohemorrhagic Escherichia coli Infections and the Hemolytic-Uremic Syndrome

3. Infection by Shiga Toxin-Producing Escherichia coli : An Overview

4. Modulation of the enterohemorrhagicE. colivirulence program through the human gastrointestinal tract

5. The interaction between bacteria and bile

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