Complete Genome Sequence of Bifidobacterium animalis subsp. lactis BB-12, a Widely Consumed Probiotic Strain

Author:

Garrigues Christel1,Johansen Eric2,Pedersen Martin B.1

Affiliation:

1. Departments of Physiology

2. Innovation Management, Chr Hansen A/S, Hørsholm, Denmark

Abstract

ABSTRACT Bifidobacterium animalis subsp. lactis BB-12 is a commercially available probiotic strain used throughout the world in a variety of functional foods and dietary supplements. The benefits of BB-12 have been documented in a number of independent clinical trials. Determination of the complete genome sequence reveals a single circular chromosome of 1,942,198 bp with 1,642 predicted protein-encoding genes, 4 rRNA operons, and 52 tRNA genes. Knowledge of this sequence will lead to insight into the specific features which give this strain its probiotic properties.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference8 articles.

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3. Garrigues, C., B. Stuer-Lauridsen, and E. Johansen. 2005. Characterisation of Bifidobacterium animalis subsp. lactis BB-12 and other probiotic bacteria using genomics, transcriptomics and proteomics. Aust. J. Dairy Technol. 60 : 84-92.

4. Genome Sequence of the Probiotic Bacterium Bifidobacterium animalis subsp. lactis AD011

5. Larsen, C. N., S. Nielsen, P. Kæstel, E. Brockmann, M. Bennedsen, H. R. Christensen, D. C. Eskesen, B. L. Jacobsen, and K. F. Michaelsen. 2006. Dose-response study of probiotic bacteria Bifidobacterium animalis subsp. lactis BB-12 and Lactobacillus paracasei subsp. paracasei CRL-341 in healthy young adults. Eur. J. Clin. Nutr. 60 : 1284-1293.

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