Kinetic and Cross-Sectional Studies on the Genesis of Hypoargininemia in Severe Pediatric Plasmodium falciparum Malaria-Reference-Cited by-同舟云学术

Kinetic and Cross-Sectional Studies on the Genesis of Hypoargininemia in Severe Pediatric Plasmodium falciparum Malaria

Published:2019-04 Issue:4 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Rubach Matthew P.¹²,Zhang Haoyue³,Florence Salvatore M.⁴,Mukemba Jackson P.⁴,Kalingonji Ayam R.⁴,Anstey Nicholas M.⁵,Yeo Tsin W.⁵⁶,Lopansri Bert K.⁷⁸,Thompson J. Will⁹,Mwaikambo Esther D.⁴,Young Sarah³,Millington David S.³,Weinberg J. Brice¹⁰¹¹,Granger Donald L.⁷¹²

Affiliation:

1. Duke University, Division of Infectious Diseases & International Health, Department of Medicine, Durham, North Carolina, USA

2. Duke University, Duke Global Health Institute, Durham, North Carolina, USA

3. Duke University, Duke Medicine Biochemical Genetics Laboratory, Durham, North Carolina, USA

4. Hubert Kairuki Memorial University, Dar es Salaam, United Republic of Tanzania

5. Menzies School of Health Research, Charles Darwin University, Casuarina, NT, Australia

6. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore

7. University of Utah School of Medicine, Division of Infectious Diseases, Department of Medicine, Salt Lake City, Utah, USA

8. Department of Medicine, Intermountain Medical Center, Murray, Utah, USA

9. Duke University, Department of Pharmacology and Cancer Biology, Durham, North Carolina, USA

10. Durham VA Medical Center, Durham, North Carolina, USA

11. Duke University, Division of Hematology, Department of Medicine, Durham, North Carolina, USA

12. Salt Lake City VA Medical Center, Salt Lake City, Utah, USA

Abstract

The low bioavailability of nitric oxide (NO) and its precursor, arginine, contributes to the microvascular pathophysiology of severe falciparum malaria. To better characterize the mechanisms underlying hypoargininemia in severe malaria, we measured the plasma concentrations of amino acids involved in de novo arginine synthesis in children with uncomplicated falciparum malaria (UM; n = 61), children with cerebral falciparum malaria (CM; n = 45), and healthy children (HC; n = 109).

Funder

Australian National Health and Medical Research Council

United States Veterans Affairs Medical Research Service

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | Fogarty International Center

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00655-18

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