Metagenomic Next-Generation Sequencing of Plasma for Diagnosis of COVID-19-Associated Pulmonary Aspergillosis-Reference-Cited by-同舟云学术

Metagenomic Next-Generation Sequencing of Plasma for Diagnosis of COVID-19-Associated Pulmonary Aspergillosis

Published:2023-03-23 Issue:3 Volume:61 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Hoenigl Martin¹²^ORCID,Egger Matthias¹²^ORCID,Price Jessica³,Krause Robert¹²,Prattes Juergen¹⁴⁵,White P. Lewis³⁶^ORCID

Affiliation:

1. Division of Infectious Diseases, Excellence Center for Medical Mycology, Department of Internal Medicine, Medical University of Graz, Graz, Austria

2. BioTechMed, Graz, Austria

3. Public Health Wales, Microbiology Cardiff, University Hospital of Wales, Cardiff, United Kingdom

4. University of Cologne, Cologne, Germany

5. University Hospital of Cologne, Department 1 for Internal Medicine, Infectious Diseases, Excellence Center for Medical Mycology, Cologne, Germany

6. Division of Infection and Immunity, Center for Trials Research, Cardiff University, Cardiff, United Kingdom

Abstract

Timely diagnosis remains an unmet need in non-neutropenic patients at risk for aspergillosis, including those with COVID-19-associated pulmonary aspergillosis (CAPA), which in its early stages is characterized by tissue-invasive growth of the lungs with limited angioinvasion. Currently available mycological tests show limited sensitivity when testing blood specimens.

Funder

Gilead Sciences

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/jcm.01859-22

Reference30 articles.

1. Lung epithelial and myeloid innate immunity in influenza-associated or COVID-19-associated pulmonary aspergillosis: an observational study

2. COVID-19-associated fungal infections

3. Risk factors and outcome of pulmonary aspergillosis in critically ill coronavirus disease 2019 patients—a multinational observational study by the European Confederation of Medical Mycology