Plasma Microbial Cell-Free DNA Sequencing from over 15,000 Patients Identified a Broad Spectrum of Pathogens-Reference-Cited by-同舟云学术

Plasma Microbial Cell-Free DNA Sequencing from over 15,000 Patients Identified a Broad Spectrum of Pathogens

Published:2023-07-13 Issue: Volume: Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Park Sarah Y.¹^ORCID,Chang Eliza J¹,Ledeboer Nathan²,Messacar Kevin³,Lindner Martin S.¹,Venkatasubrahmanyam Shivkumar¹,Wilber Judith C.¹,Vaughn Marla Lay¹,Bercovici Sivan¹,Perkins Bradley A.¹,Nolte Frederick S.¹^ORCID

Affiliation:

1. Karius, Redwood City, California, USA

2. Medical College of Wisconsin, Milwaukee, Wisconsin, USA

3. University of Colorado, Children’s Hospital Colorado, Aurora, Colorado, USA

Abstract

Microbial cell-free DNA (mcfDNA) sequencing is an emerging infectious disease diagnostic tool which enables unbiased pathogen detection and quantification from plasma. The Karius Test, a commercial mcfDNA sequencing assay developed by and available since 2017 from Karius, Inc. (Redwood City, CA), detects and quantifies mcfDNA as molecules/μL in plasma.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/jcm.01855-22

Reference74 articles.

1. Advancements in Next-Generation Sequencing

2. Basic local alignment search tool

3. Numerous uncharacterized and highly divergent microbes which colonize humans are revealed by circulating cell-free DNA

4. Exploring the utility of multiplex infectious disease panel testing for diagnosis of infection in different body sites: a joint report of the association for molecular pathology, american society for microbiology, infectious diseases society of america, and pan american society for clinical virology;Lewinski M;The J Molecular Diagnostics

5. Utility of Broad-Range PCR Sequencing for Infectious Diseases Clinical Decision Making: a Pediatric Center Experience

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