A Novel, Widespread qacA Allele Results in Reduced Chlorhexidine Susceptibility in Staphylococcus epidermidis-Reference-Cited by-同舟云学术

A Novel, Widespread qacA Allele Results in Reduced Chlorhexidine Susceptibility in Staphylococcus epidermidis

Published:2019-06 Issue:6 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Addetia Amin¹,Greninger Alexander L.²,Adler Amanda¹,Yuan Shuhua³,Makhsous Negar²,Qin Xuan¹²,Zerr Danielle M.¹⁴

Affiliation:

1. Seattle Children’s Research Institute, Seattle, Washington, USA

2. Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA

3. Department of Pediatric Pulmonology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China

4. Department of Pediatrics, University of Washington, Seattle, Washington, USA

Abstract

Chlorhexidine gluconate (CHG) is a topical antiseptic widely used in health care settings. In Staphylococcus spp., the pump QacA effluxes CHG, while the closely related QacB cannot due to a single amino acid substitution.

Funder

HHS | NIH | National Cancer Institute

St. Baldrick's Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02607-18

Reference76 articles.

1. Coagulase-Negative Staphylococci

2. Characterization of theN-Acetylglucosaminyltransferase Activity Involved in the Biosynthesis of the Staphylococcus epidermidisPolysaccharide Intercellular Adhesin

3. Current concepts in biofilm formation of Staphylococcus epidermidis

4. A 140-kilodalton extracellular protein is essential for the accumulation of Staphylococcus epidermidis strains on surfaces

5. Staphylococcus epidermidis — the 'accidental' pathogen

Cited by 14 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The mobilome landscape of biocide-resistance in Brazilian ESKAPE isolates;Brazilian Journal of Microbiology;2024-07-19

2. Impact of clonal lineages on susceptibility of Staphylococcus lugdunensis to chlorhexidine digluconate and chloride benzalkonium;BMC Microbiology;2023-11-13

3. Antimicrobial resistance and virulence profiles of staphylococci isolated from clinical bovine mastitis;Frontiers in Microbiology;2023-06-29

4. The role of TMS 12 in the staphylococcal multidrug efflux protein QacA;Journal of Antimicrobial Chemotherapy;2023-04-26

5. Efflux-mediated tolerance to cationic biocides, a cause for concern?;Microbiology;2022-11-30