Interplay among IncA and bla KPC -Carrying Plasmids in Citrobacter freundii-Reference-Cited by-同舟云学术

Interplay among IncA and bla KPC -Carrying Plasmids in Citrobacter freundii

Published:2019-05 Issue:5 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bitar Ibrahim¹,Caltagirone Mariasofia²,Villa Laura³,Mattioni Marchetti Vittoria²,Nucleo Elisabetta²,Sarti Mario⁴,Migliavacca Roberta²,Carattoli Alessandra⁵

Affiliation:

1. Faculty of Medicine, Biomedical Center, Charles University, Pilsen, Czech Republic

2. Unit of Microbiology and Clinical Microbiology, Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy

3. Istituto Superiore di Sanità, Rome, Italy

4. S. Agostino-Estense-Baggiovara Hospital, Modena, Italy

5. Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy

Abstract

We report two KPC-producing Citrobacter freundii isolates from unrelated patients. In one case, bla KPC-2 was harbored on a novel variant of a Tn 4401 transposon of an IncN plasmid conjugated together with a coresident IncA plasmid, whereas in the other one, bla KPC-3 was on a Tn 4401a transposon located on an IncX3-IncA self-conjugative plasmid fusion.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02609-18

Reference14 articles.

1. Citrobacter freundii carrying blaKPC-2 and blaNDM-1: characterization by whole genome sequencing

2. Insights into a Novel blaKPC-2-Encoding IncP-6 Plasmid Reveal Carbapenem-Resistance Circulation in Several Enterobacteriaceae Species from Wastewater and a Hospital Source in Spain

3. Functional Characterization of Tn4401, a Tn3-Based Transposon Involved inblaKPCGene Mobilization

4. Emergence of Escherichia coli Sequence Type 131 (ST131) and ST3948 with KPC-2, KPC-3 and KPC-8 carbapenemases from a Long-Term Care and Rehabilitation Facility (LTCRF) in Northern Italy

5. Outbreak of Citrobacter freundii carrying VIM-1 in an Italian Hospital, identified during the carbapenemases screening actions, June 2012

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