Mechanisms of Macrolide Resistance among Streptococcus pneumoniae Isolates from Russia

Author:

Reinert Ralf R.1,Filimonova Olga Y.2,Al-Lahham Adnan3,Grudinina Svetlana A.2,Ilina Elena N.4,Weigel Linda M.5,Sidorenko Sergey V.2

Affiliation:

1. Institute for Medical Microbiology, National Reference Center for Streptococci, University Hospital (RWTH), Aachen, Germany

2. National Research Center of Antibiotics, Moscow, Russia

3. German Jordanian University, School of Applied Medical Sciences, Amman, Jordan

4. Institute of Physico-Chemical Medicine, Moscow, Russia

5. Centers for Disease Control and Prevention, Atlanta, Georgia

Abstract

ABSTRACT Among 76 macrolide-nonsusceptible Streptococcus pneumoniae isolates collected between 2003 and 2005 from Central Russia, the resistance mechanisms detected in the isolates included erm (B) alone (50%), mef alone [ mef (E), mef (I), or a different mef subclass; 19.7%], or both erm (B) and mef (E) (30.3%). Isolates with dual resistance genes [ erm (B) and mef (E)] belonged to clonal complex CC81 or CC271.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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