Phenyl-Lactic Acid Is an Active Ingredient in Bactericidal Supernatants of Lactobacillus crispatus-Reference-Cited by-同舟云学术

Phenyl-Lactic Acid Is an Active Ingredient in Bactericidal Supernatants of Lactobacillus crispatus

Published:2021-09-08 Issue:19 Volume:203 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Abdul-Rahim Omar¹,Wu Qihao²,Price Travis K.¹,Pistone Giuseppe¹,Diebel Katherine¹,Bugni Tim S.²,Wolfe Alan J.¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA

2. School of Pharmacy, University of Wisconsin—Madison, Madison, Wisconsin, USA

Abstract

Although Lactobacillus crispatus is an established commensal microbe frequently used in probiotics, its protective role in the bladder microbiome has not been clarified. We report here that some urinary isolates of L. crispatus exhibit bactericidal activity, primarily due to its ability to excrete phenyl-lactic acid into its environment.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00360-21

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