The Proteome of Extracellular Vesicles Produced by the Human Gut Bacteria Bacteroides thetaiotaomicron In Vivo Is Influenced by Environmental and Host-Derived Factors

Author:

Stentz Régis1ORCID,Jones Emily1,Juodeikis Rokas1,Wegmann Udo2,Guirro Maria34,Goldson Andrew J.5,Brion Arlaine5,Booth Catherine5,Sudhakar Padhmanand167,Brown Ian R.8,Korcsmáros Tamás16,Carding Simon R.19ORCID

Affiliation:

1. Gut Microbes and Health Research Programme, Quadram Institute Bioscience, Norwich, United Kingdom

2. School of Chemistry, University East Anglia, Norwich, United Kingdom

3. Biochemistry and Biotechnology Department, Nutrigenomics Research Group, Universitat Rovira i Virgili, Tarragona, Spain

4. Eurecat, Centre Tecnològic de Catalunya, Centre for Omic Sciences (COS), Joint Unit Universitat Rovira i Virgili-EURECAT, Unique Scientific and Technical Infrastructures (ICTS), Reus, Spain

5. Core Science Resources Quadram Institute Bioscience, Norwich, United Kingdom

6. Earlham Institute, Norwich, United Kingdom

7. Department of Chronic Diseases, Metabolism and Ageing, TARGID, KU Leuven, Leuven, Belgium

8. School of Biosciences, University of Kent, Canterbury, United Kingdom

9. Norwich Medical School, University East Anglia, Norwich, United Kingdom

Abstract

The gastrointestinal tract (GIT) harbors a complex community of microbes termed the microbiota that plays a role in maintaining the host’s health and wellbeing. How this comes about and the nature of microbe-host cell interactions in the GIT is still unclear.

Funder

UKRI | Biotechnology and Biological Sciences Research Council

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

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