Importance of Clonal Complex 258 and IncF K2-like Plasmids among a Global Collection of Klebsiella pneumoniae with bla KPC-Reference-Cited by-同舟云学术

Importance of Clonal Complex 258 and IncF K2-like Plasmids among a Global Collection of Klebsiella pneumoniae with bla KPC

Published:2017-04 Issue:4 Volume:61 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Peirano Gisele¹²,Bradford Patricia A.³,Kazmierczak Krystyna M.⁴,Chen Liang⁵,Kreiswirth Barry N.⁵,Pitout Johann D. D.¹²⁶⁷

Affiliation:

1. Departments of Pathology & Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada

2. Division of Microbiology, Calgary Laboratory Services, Calgary, Alberta, Canada

3. AstraZeneca Pharmaceuticals LP, Waltham, Massachusetts, USA

4. International Health Management Associates, Schaumburg, Illinois, USA

5. Public Health Research Institute TB Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA

6. Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada

7. University of Pretoria, Pretoria, South Africa

Abstract

ABSTRACT This study was designed to determine the global distribution of clonal complex (CC) 258 and IncFII K2-like plasmids with bla KPC among 522 global Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae isolates. CC258 (i.e., ST258 [clades I and II], ST11, ST340, and ST512) and ST147 were statistically associated with IncFII K2-like KPC-containing plasmids and may possess an epidemiological advantage over isolates that harbored non-IncF KPC-harboring plasmids.

Funder

Calgary Laboratory Services

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02610-16

Reference18 articles.

1. Carbapenemase-Producing Klebsiella pneumoniae, a Key Pathogen Set for Global Nosocomial Dominance

2. Carbapenemase-producing Klebsiella pneumoniae: molecular and genetic decoding

3. Complete Sequence of ablaKPC-2-Harboring IncFIIK1Plasmid from a Klebsiella pneumoniae Sequence Type 258 Strain