Cloning and Characterization of the Biosynthetic Gene Cluster for Tomaymycin, an SJG-136 Monomeric Analog-Reference-Cited by-同舟云学术

Cloning and Characterization of the Biosynthetic Gene Cluster for Tomaymycin, an SJG-136 Monomeric Analog

Published:2009-05 Issue:9 Volume:75 Page:2958-2963
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Li Wei¹,Chou ShenChieh¹,Khullar Ankush¹,Gerratana Barbara¹

Affiliation:

1. Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742

Abstract

ABSTRACT Tomaymycin produced by Streptomyces achromogenes is a naturally produced pyrrolobenzodiazepine (PBD). The biosynthetic gene cluster for tomaymycin was identified and sequenced. The gene cluster analysis reveals a novel biosynthetic pathway for the anthranilate moiety of PBDs. Gene replacement and chemical complementation studies were used to confirm the proposed biosynthetic pathway.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.02325-08

Reference30 articles.

1. Alley, M. C., M. G. Hollingshead, C. M. Pacula-Cox, W. R. Waud, J. A. Hartley, P. W. Howard, S. J. Gregson, D. E. Thurston, and E. A. Sausville. 2004. SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity. 2. Efficacy evaluations. Cancer Res.64:6700-6706.

2. Antonow, D., N. Cooper, P. W. Howard, and D. E. Thurston. 2007. Parallel synthesis of a novel C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) library. J. Comb. Chem.9:437-445.

3. Brahme, N. M., J. E. Gonzalez, J. P. Rolls, E. J. Hessler, S. Mizsak, and L. H. Hurley. 1984. Biosynthesis of the lincomycins. 1. Studies using stable isotopes on the biosynthesis of the propyl-l-hygric and ethyl-l-hygric acid moieties of lincomycin-A and lincomycin-B. J. Am. Chem. Soc.106:7873-7878.

4. Calisti, C., A. G. Ficca, P. Barghini, and M. Ruzzi. 2008. Regulation of ferulic catabolic genes in Pseudomonas fluorescens BF13: involvement of a MarR family regulator. Appl. Microbiol. Biotechnol.80:475-483.

5. Reference deleted.

Cited by 84 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Application of Imine Reductase in Bioactive Chiral Amine Synthesis;Organic Process Research & Development;2024-07-11

2. The specificity of intermodular recognition in a prototypical nonribosomal peptide synthetase depends on an adaptor domain;Science Advances;2024-06-21

3. Discovery and characterization of l-DOPA 2,3-dioxygenase from Streptomyces hygroscopicus jingganensis;Archives of Biochemistry and Biophysics;2024-05

4. The shikimate pathway: gateway to metabolic diversity;Natural Product Reports;2024

5. Pyrrolobenzodiazepines: natural sources, therapeutic uses, and future in neurological treatments;Medicinal Chemistry Research;2023-12-18