SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway-Reference-Cited by-同舟云学术

SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway

Published:2021-09-09 Issue:19 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Chen Da-Yuan¹²,Khan Nazimuddin¹²,Close Brianna J.²³,Goel Raghuveera K.¹⁴,Blum Benjamin¹⁴,Tavares Alexander H.¹²,Kenney Devin²³,Conway Hasahn L.¹²,Ewoldt Jourdan K.⁵⁶⁷,Chitalia Vipul C.⁸⁹¹⁰,Crossland Nicholas A.²¹¹,Chen Christopher S.⁵⁶⁷,Kotton Darrell N.¹²¹³,Baker Susan C.¹⁴^ORCID,Fuchs Serge Y.¹⁵,Connor John H.²³^ORCID,Douam Florian²³,Emili Andrew¹⁴,Saeed Mohsan¹²^ORCID

Affiliation:

1. Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, USA

2. National Emerging Infectious Diseases Laboratories, Boston University, Boston, Massachusetts, USA

3. Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts, USA

4. Center for Network Systems Biology, Boston University, Boston, Massachusetts, USA

5. Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA

6. Biological Design Center, Boston University, Boston, Massachusetts, USA

7. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA

8. Renal Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA

9. Boston Veterans Affairs Healthcare System, Boston, Massachusetts, USA

10. Institute of Medical Engineering and Sciences, MA Institute of Technology, Cambridge, Massachusetts, USA

11. Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts, USA

12. Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, Massachusetts, USA

13. The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA

14. Department of Microbiology and Immunology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA

15. Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Abstract

SARS-CoV-2 can infect various organs in the human body, but the molecular interface between the virus and these organs remains unexplored. In this study, we generated a panel of highly infectible human cell lines originating from various body organs and employed these cells to identify cellular processes commonly or distinctly disrupted by SARS-CoV-2 in different cell types.

Funder

Boston University Startup Funds

Evergrande MassCPR Award

Peter Paul Career Development Award

National Science Foundation Graduate Research Award

National Science Foundation Nanosystems Engineering Research Center for Directed Multiscale Assembly of Cellular Metamaterials

HHS | NIH | National Cancer Institute

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology