Leukocyte-mediated lysis of infected hepatocytes during listeriosis occurs in mice depleted of NK cells or CD4+ CD8+ Thy1.2+ T cells-Reference-Cited by-同舟云学术

Leukocyte-mediated lysis of infected hepatocytes during listeriosis occurs in mice depleted of NK cells or CD4+ CD8+ Thy1.2+ T cells

Published:1993-06 Issue:6 Volume:61 Page:2703-2707
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Conlan J W¹,Dunn P L¹,North R J¹

Affiliation:

1. Trudeau Institute, Inc., Saranac Lake, New York 12983.

Abstract

An important early component of defense against listeriosis in mice is the lysis of infected hepatocytes by leukocytes that accumulate at foci of infection in the liver. This serves to release Listeria monocytogenes from permissive parenchymal cells for ingestion and inactivation by phagocytic cells. It is shown here that lysis of infected hepatocytes is as extensive in mice depleted of T cells or NK cells as it is in control mice. This supports the original interpretation that hepatocyte lysis is mediated mainly by neutrophils.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.61.6.2703-2707.1993

Reference24 articles.

1. Expression of systemic protection and delayed-type hypersensitivity to Listeria monocytogenes is mediated by different T-cell subsets;Baldridge J. R.;Infect. Immun.,1990

2. Neutrophil-mediated dissolution of infected host cells as a defense strategy against a facultative intracellular bacterium;Conlan J. W.;J. Exp. Med.,1991

3. Roles of Listeria monocytogenes virulence factors in survival: virulence factors distinct from listeriolysin are needed for the organism to survive an early neutrophil-mediated host defense mechanism;Conlan J. W.;Infect. Immun.,1992

4. Monoclonal antibody NIMP-R1O directed against the CD11b chain of the type 3 complement receptor can substitute for monoclonal antibody 5C6 to exacerbate murine listeriosis by preventing the focusing of myelomonocytic cells at infectious foci in the liver;Conlan J. W.;J. Leukocyte Biol.,1992

5. Early gamma interferon production by natural killer cells is important in defense against murine listeriosis;Dunn P. L.;Infect. Immun.,1991

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