Cytopathogenic effect in cardiac myocytes but not in cardiac fibroblasts is correlated with reovirus-induced acute myocarditis

Author:

Baty C J1,Sherry B1

Affiliation:

1. Department of Microbiology, Pathology, and Parasitology, College of Veterinary Medicine, North Carolina State University, Raleigh 27606.

Abstract

A panel of reovirus strains was used to compare myocarditic potential with induction of cytopathic effect in primary cardiac myocyte and cardiac fibroblast cultures. The results suggest that viral cytopathogenicity in cardiac myocytes, but not in cardiac fibroblasts, is a determinant of reoviral myocarditis.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference27 articles.

1. Baty C. J. and B. Sherry. Unpublished data.

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3. Experimental reovirus myocarditis in newborn mice: electron microscopic observations;GoIler T.;Virchows Arch. B Cell Pathol.,1986

4. Arrhythmic movements of myocardial cells in culture and their improvement with antiarrhythmic drugs;Goshima K.;J. Mol. Cell. Cardiol.,1976

5. Pathogenesis of acute myocardial necrosis in inbred mice infected with coxsackievirus B3;Grun J. B.;Microb. Pathog.,1988

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