Immunization with Treponema pallidum endoflagella alters the course of experimental rabbit syphilis-Reference-Cited by-同舟云学术

Immunization with Treponema pallidum endoflagella alters the course of experimental rabbit syphilis

Published:1990-09 Issue:9 Volume:58 Page:3158-3161
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Champion C I¹,Miller J N¹,Borenstein L A¹,Lovett M A¹,Blanco D R¹

Affiliation:

1. Department of Microbiology, School of Medicine, University of California, Los Angeles 90024.

Abstract

Rabbits were immunized over a 32-week period with a total of 450 micrograms of purified Treponema pallidum endoflagella. As measured by enzyme-linked immunosorbent assay, sera from immunized rabbits had antiendoflagellar antibody titers that were fivefold greater than titers of sera from infected immune rabbits and patients with secondary disease. Sera from all immunized animals possessed complement-dependent treponemicidal activity as measured by in vitro immobilization. Immunized animals challenged with virulent T. pallidum were not protected from symptomatic infection but showed an altered course of lesion development.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.58.9.3158-3161.1990

Reference20 articles.

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2. Antigenic and structural characterization of Treponema pallidum (Nichols strain) endoflagella;Blanco D. R.;Infect. Immun.,1988

3. Correlation of treponemicidal activity in normal human serum with the presence of IgG antibody directed against polypeptides of Treponema phagedenis biotype Reiter and Treponema pallidum, Nichols strain;Blanco D. R.;J. Immunol.,1986

4. The antigenic interrelationship between the endoflagella of Treponema phagedenis biotype Reiter and Treponema pallidum Nichols strain. . I. Treponemicidal activity of cross-reactive endoflagellar antibodies against T. pallidum;Blanco D. R.;J. Immunol.,1986

5. Complement activation limits the rate of in vitro treponemicidal activity and correlates with antibody mediated aggregation of Treponema pallidum rare outer membrane protein (TROMP);Blanco D. R.;J. Immunol.,1990

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