Comparison of commercial diagnostic tests for identification of serogroup antigens of Neisseria meningitidis

Author:

van der Ende A1,Schuurman I G1,Hopman C T1,Fijen C A1,Dankert J1

Affiliation:

1. Department of Medical Microbiology, University of Amsterdam, The Netherlands.

Abstract

In the study that is described the sensitivities and specificities of three commercial tests and the standard Reference Laboratory test, used since 1961, to identify Neisseria meningitidis serogroups were compared. The tests marketed by Difco, Murex/Wellcome, and Sanofi/Pasteur showed overall sensitivities of 92, 95, and 100%, respectively, and specificities of 67, 88, and 82%, respectively. When limited to the common serogroups A, B, and C, the three tests yielded sensitivities of 93, 97, and 100%, respectively, and specificities of 98, 100, and 98%, respectively. However, determination of the uncommon serogroups X, W-135, Y, Z, and 29E with these tests is either unreliable or not possible.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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3. Fijen C. A. P. E. J. Kuijper A. J. Hannema A. G. Sjöholm and J. P. M. van Putten. 1989. Complement deficiencies in patients over ten years old with meningococcal disease due to uncommon serogroups. Lancet ii:585-588.

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5. Serotype antigens of Neisseria meningitidis and a proposed scheme for designation of serotypes;Frasch C. E.;Rev. Infect. Dis.,1985

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