SARS-CoV-2 Infection Severity Is Linked to Superior Humoral Immunity against the Spike

Author:

Guthmiller Jenna J.1,Stovicek Olivia1,Wang Jiaolong1,Changrob Siriruk1,Li Lei1,Halfmann Peter2,Zheng Nai-Ying1,Utset Henry1,Stamper Christopher T.3,Dugan Haley L.3,Miller William D.4,Huang Min1,Dai Ya-Nan5,Nelson Christopher A.5,Hall Paige D.5,Jansen Maud6,Shanmugarajah Kumaran7,Donington Jessica S.7,Krammer Florian8ORCID,Fremont Daved H.5,Joachimiak Andrzej910,Kawaoka Yoshihiro2ORCID,Tesic Vera11ORCID,Madariaga Maria Lucia7,Wilson Patrick C.13ORCID

Affiliation:

1. Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA

2. Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA

3. Committee on Immunology, University of Chicago, Chicago, Illinois, USA

4. Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois, USA

5. Department of Pathology and Immunology and Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, Washington University School of Medicine, St. Louis, Missouri, USA

6. Department of Medicine, University of Chicago, Chicago, Illinois, USA

7. Department of Surgery, University of Chicago, Chicago, Illinois, USA

8. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

9. Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois, USA

10. Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, Illinois, USA

11. Department of Pathology, University of Chicago, Chicago, Illinois, USA

Abstract

With the ongoing pandemic, it is critical to understand how natural immunity against SARS-CoV-2 and COVID-19 develops. We have identified that subjects with more severe COVID-19 disease mount a more robust and neutralizing antibody response against SARS-CoV-2 spike protein.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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