Suppression of lymphocyte response to concanavalin A by mucopolysaccharide material from Treponema pallidum-infected rabbits

Author:

Bey R F,Johnson R C,Fitzgerald T J

Abstract

The testicular fluid and serum from rabbits infected intratesticularly with Treponema pallidum inhibited the mitogenic response of normal rabbit peripheral blood lymphocytes to concanavalin A. Mucopolysaccharide material present in the testicular fluid and serum was associated with the lymphocyte-inhibitory activity. Degradation of the mucopolysaccharide material with hyaluronidase resulted in the loss of the inhibitory activity of testicular fluid and serum of T. pallidu-infected rabbits.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference32 articles.

1. Isolation of monuclear cells and granulocytes from human blood;Boyum A.;Scand. J. Clin. Lab. Invest. Suppl.,1968

2. Runting syndrome in neonatal rabbits infected with Treponema pallidum;Festenstein H.;Clin. Exp. Immunol.,1967

3. Scanning electron microscopy of Treponema pallidum (Nichols strain) attached to culture mammalian cells;Fitzgerald T. J.;J. Bacteriol.,1976

4. Surface mucopolysaccharides of Treponema pallidum;Fitzgerald T. J.;Infect. Immun.,1979

5. Relationship of Treponema pallidum to acidic mucopolysaccharides;Fitzgerald T. J.;Infect. Immun.,1979

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