Simultaneous or Prior Activation of Intrahepatic Type I Interferon Signaling Leads to Hepatitis B Virus Persistence in a Mouse Model-Reference-Cited by-同舟云学术

Simultaneous or Prior Activation of Intrahepatic Type I Interferon Signaling Leads to Hepatitis B Virus Persistence in a Mouse Model

Published:2021-11-23 Issue:24 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Zou Shi¹,Du Yanqin¹²^ORCID,Huang Shunmei¹³,Chen Mingfa⁴,Yang Xiaoli¹,Li Sumeng¹,Chen Yingshan⁵,Han Meihong¹,Li Jia¹,Yu Qing¹,Littwitz-Salomon Elisabeth²,Huang Hongming¹,Trilling Mirko²^ORCID,Liu Shi⁶,Pei Rongjuan⁵,Liu Jia¹,Wang Baoju¹,Zheng Xin¹,Lu Mengji²,Dittmer Ulf²,Sun Shuilin⁷,Yang Dongliang¹,Wu Jun¹^ORCID

Affiliation:

1. Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

2. Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

3. Department of Geriatrics, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China

4. Department of Infectious Diseases, Shenzheng Luohu’s Hospital, Shenzheng, China

5. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China

6. State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, China

7. Department of Infectious Diseases, the Second Affiliated Hospital of Nanchang University, Nanchang, China

Abstract

IFN-I plays a double-edged sword role during chronic HBV infection. Here, we identified that application of IFN-I at different time points causes contrast outcomes.

Funder

MOST | International Science and Technology Cooperation Programme

MOST | National Major Science and Technology Projects of China

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00034-21

Reference40 articles.

1. Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection