Flexibility of the Rotavirus NSP2 C-Terminal Region Supports Factory Formation via Liquid-Liquid Phase Separation-Reference-Cited by-同舟云学术

Flexibility of the Rotavirus NSP2 C-Terminal Region Supports Factory Formation via Liquid-Liquid Phase Separation

Published:2023-02-28 Issue:2 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Nichols Sarah L.¹,Nilsson Emil M.¹,Brown-Harding Heather¹,LaConte Leslie E. W.²³,Acker Julia⁴,Borodavka Alexander⁴,McDonald Esstman Sarah¹^ORCID

Affiliation:

1. Department of Biology, Wake Forest University, Winston-Salem, North Carolina, USA

2. Fralin Biomedical Research Institute, Roanoke, Virginia, USA

3. Department of Basic Science Education, Virginia Tech Carilion School of Medicine, Roanoke, Virginia, USA

4. Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

Abstract

Viruses often condense the materials needed for their replication into discrete intracellular factories. For rotaviruses, agents of severe gastroenteritis in children, factory formation is mediated in part by an octameric protein called NSP2.

Funder

HHS | National Institutes of Health

Wellcome Trust

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00039-23

Reference52 articles.

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