Adeno-associated Virus 9 Structural Rearrangements Induced by Endosomal Trafficking pH and Glycan Attachment-Reference-Cited by-同舟云学术

Adeno-associated Virus 9 Structural Rearrangements Induced by Endosomal Trafficking pH and Glycan Attachment

Published:2021-09-09 Issue:19 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Penzes Judit J.¹^ORCID,Chipman Paul¹,Bhattacharya Nilakshee²,Zeher Allison³,Huang Rick³,McKenna Robert¹^ORCID,Agbandje-McKenna Mavis¹^ORCID

Affiliation:

1. Department of Biochemistry & Molecular Biology, Center for Structural Biology, The McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, Florida, USA

2. Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, USA

3. Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA

Abstract

There are 13 distinct Adeno-associated virus (AAV) serotypes that are structurally homologous and whose capsid proteins (VP1 to −3) are similar in amino acid sequence. However, AAV9 is one of the most commonly studied and is used as a gene therapy vector.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00843-21

Reference93 articles.

1. ICTV Virus Taxonomy Profile: Parvoviridae

2. Adeno-associated virus vectors preferentially transduce cells in S phase.

3. Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy