Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator-Reference-Cited by-同舟云学术

Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator

Published:1997-11 Issue:11 Volume:71 Page:8856-8859
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Kato N¹,Lan K H¹,Ono-Nita S K¹,Shiratori Y¹,Omata M¹

Affiliation:

1. Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan. kato-2im@h.u-tokyo.ac.jp

Abstract

The hepatitis C virus (HCV) nonstructural region 5A (NS5A) protein, without its 146 amino-terminal amino acids and fused to the DNA-binding domain of GAL4, strongly activates transcription in yeast and human hepatoma cells. Transcriptional activation by the HCV NS5A protein may play a role in viral replication and hepatocarcinogenesis.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.71.11.8856-8859.1997

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