Adaptive Radioresistance of Enterohemorrhagic Escherichia coli O157:H7 Results in Genomic Loss of Shiga Toxin-Encoding Prophages-Reference-Cited by-同舟云学术

Adaptive Radioresistance of Enterohemorrhagic Escherichia coli O157:H7 Results in Genomic Loss of Shiga Toxin-Encoding Prophages

Published:2023-04-26 Issue:4 Volume:89 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Gaougaou Ghizlane¹²,Vincent Antony T.¹,Krylova Kateryna¹,Habouria Hajer¹,Bessaiah Hicham¹,Baraketi Amina²,Veyrier Frédéric J.¹^ORCID,Dozois Charles M.¹^ORCID,Déziel Eric¹^ORCID,Lacroix Monique¹²

Affiliation:

1. INRS-Centre Armand-Frappier Santé Biotechnologie, Laval, Québec, Canada

2. Research Laboratories in Sciences Applied to Food, Canadian Irradiation Centre, INRS-Centre Armand-Frappier Santé Biotechnologie, Laval, Québec, Canada

Abstract

Gamma irradiation of food products can provide an effective means of eliminating bacterial pathogens such as enterohemorrhagic Escherichia coli (EHEC) O157:H7, a significant foodborne pathogen that can cause severe disease due to the production of Stx. To decipher the mechanisms of adaptive resistance of the O157:H7 strain EDL933, we evolved clones of this bacterium resistant to a lethal dose of gamma irradiation by repeatedly exposing bacterial cells to irradiation following a growth restoration over six successive passages.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/aem.01306-22

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