NisI Maturation and Its Influence on Nisin Resistance in Lactococcus lactis-Reference-Cited by-同舟云学术

NisI Maturation and Its Influence on Nisin Resistance in Lactococcus lactis

Published:2020-09-17 Issue:19 Volume:86 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Liu Jiaheng¹²³,Xiong Hui¹²³,Du Yuhui⁴,Wiwatanaratanabutr Itsanun⁵⁶,Wu Xiaofang¹²³,Zhao Guangrong¹²³,Zhu Hongji¹²,Caiyin Qinggele¹²,Qiao Jianjun¹²³^ORCID

Affiliation:

1. Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, China

2. School of Chemical Engineering and Technology, Tianjin University, Tianjin, China

3. SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, China

4. Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, China

5. Center of Excellence in Applied Biosciences, King Mongkut’s Institute of Technology Ladkrabang, Bangkok, Thailand

6. Department of Plant Production Technology, Faculty of Agricultural Technology, King Mongkut’s Institute of Technology Ladkrabang, Bangkok, Thailand

Abstract

Nisin, a safe and natural antimicrobial peptide, has a long and impressive history as a food preservative and is also considered a novel candidate to alleviate the increasingly serious threat of antibiotic resistance. Nisin is produced by certain L. lactis strains. The nisin immunity protein NisI, a membrane-bound lipoprotein, is expressed by nisin producers to avoid suicidal action. Here, we report the roles of Lsp and Lgt in NisI maturation and nisin resistance of L. lactis F44. The results verified the importance of Lsp to NisI-conferred immunity and Lgt to localization. Our study revealed the process of NisI maturation in L. lactis and presented a potential strategy to enhance industrial nisin production.

Funder

National Key Research and Development Project of China

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.01306-20

Reference56 articles.

1. Biosynthesis and Mode of Action of Lantibiotics

2. Lantibiotics: Peptides of Diverse Structure and Function

3. Antimicrobial mechanism of lantibiotics

4. Bioengineering Lantibiotics for Therapeutic Success

5. Structure of nisin

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Harnessing cross-resistance – Sustainable nisin production from low-value food side streams using a Lactococcus lactis mutant with higher nisin-resistance obtained after prolonged chlorhexidine exposure;Bioresource Technology;2022-03