Vestibular Reactions Associated with Minocycline

Author:

Jacobson Jay A.1,Daniel Brenda

Affiliation:

1. Bureau of Epidemiology, Center for Disease Control, Atlanta, Georgia 30333

Abstract

Several recent reports have indicated that minocycline, a drug effective for meningococcal disease prophylaxis, is associated with a high incidence of vestibular side effects. In January 1975, a questionnaire on adverse reactions was completed by all 29 staff members of a North Georgia hospital who had taken minocycline at the recommended dosage after exposure to a suspected meningococcal meningitis case and by 25 age-, sex-, and occupation-matched non-treated controls. In the treated group 86% experienced moderate to severe vestibular symptoms; 84% of the symptomatic persons experienced their onset after one or two doses of 100 mg. Fifty-two percent of the treated staff members stopped taking the medication because of these effects. The symptoms resolved within 48 h after affected persons discontinued the medication. Until the safety of minocycline can be reestablished, rifampin is recommended for meningococcal disease prophylaxis, and alternative drugs are encouraged for other indications.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference17 articles.

1. Vestibular reactions to minocycline after meningococcal prophylaxis-New Jersey;Center for Disease Control.;Morbid. Mortal. Week. Rep.,1975

2. Efficacy of rifampin in treatment of meningococcal carriers;Deal W. B.;New Engl. J. Med.,1969

3. Rifampin levels in serum and saliva and effect on the meningococcal carrier state;Devine L. F.;J. Am. Med. Assoc.,1970

4. The effect of minocycline on meningococcal nasopharyngeal carrier state in naval personnel;Devine L. F.;Am. J. Epidemiol.,1971

5. Field trial of the efficacy of a previously proposed regimen using minocycline and rifampin sequentially for the elimination of meningococci from healthy carriers;Devine L. F.;Am. J. Epidemiol.,1973

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