Potent Activities of Luliconazole, Lanoconazole, and Eight Comparators against Molecularly Characterized Fusarium Species-Reference-Cited by-同舟云学术

Potent Activities of Luliconazole, Lanoconazole, and Eight Comparators against Molecularly Characterized Fusarium Species

Published:2018-05 Issue:5 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Abastabar Mahdi¹,Al-Hatmi Abdullah M. S.²³⁴^ORCID,Vafaei Moghaddam Mohammad⁵,de Hoog G. Sybren²³^ORCID,Haghani Iman¹,Aghili Seyed Reza¹,Shokohi Tahereh¹^ORCID,Hedayati Mohammad Taghi¹^ORCID,Daie Ghazvini Roshanak⁶,Kachuei Reza⁷,Rezaei-Matehkolaei Ali⁸,Makimura Koichi⁹¹⁰,Meis Jacques F.³¹¹^ORCID,Badali Hamid¹¹²^ORCID

Affiliation:

1. Invasive Fungi Research Center (IFRC), School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

2. Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands

3. Centre of Expertise in Mycology Radboud University Medical Centre/Canisius Wilhelmina Hospital, Nijmegen, The Netherlands

4. Ministry of Health, Directorate General of Health Services, Ibri, Oman

5. Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran

6. Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

7. Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran

8. Department of Medical Mycology, School of Medicine, Health Research Institute, Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

9. Laboratory of Space and Environmental Medicine, Graduate School of Medicine, Teikyo University, Tokyo, Japan

10. Teikyo University Institute of Medical Mycology, Tokyo, Japan

11. Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands

12. Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Abstract

ABSTRACT A collection of clinical ( n = 47) and environmental ( n = 79) Fusarium isolates were tested against 10 antifungal drugs, including 2 novel imidazoles. Luliconazole and lanoconazole demonstrated very low geometric mean MIC values of 0.005 and 0.013 μg/ml, respectively, compared with 0.51 μg/ml for micafungin, 0.85 μg/ml for efinaconazole, 1.12 μg/ml for natamycin, 1.18 μg/ml for anidulafungin, 1.31 μg/ml for voriconazole, 1.35 μg/ml for caspofungin, 1.9 μg/ml for amphotericin B, and 4.08 μg/ml for itraconazole. Results show that these drugs are potential candidates for (topical) treatment of skin and nail infections due to Fusarium species.

Funder

Merck

Astellas Pharma US

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00009-18

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