Sultam Thiourea Inhibition of West Nile Virus-Reference-Cited by-同舟云学术

Sultam Thiourea Inhibition of West Nile Virus

Published:2007-07 Issue:7 Volume:51 Page:2642-2645
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Barklis Eric¹,Still Amelia¹,Sabri Mohammad I.²,Hirsch Alec J.³⁴,Nikolich-Zugich Janko³⁴,Brien James³⁴,Dhenub Tenzin Choesang¹,Scholz Isabel¹,Alfadhli Ayna¹

Affiliation:

1. Vollum Institute and Department of Molecular Microbiology and Immunology, Oregon Health & Sciences University (OHSU), Portland, Oregon

2. Center for Research on Occupational and Environmental Toxicology and Department of Neurology, OHSU, Portland, Oregon

3. Department of Molecular Microbiology and Immunology and Vaccine and Gene Therapy Institute, OHSU, Portland, Oregon

4. Oregon National Primate Research Center, Beaverton, Oregon

Abstract

ABSTRACT We have identified sultam thioureas as novel inhibitors of West Nile virus (WNV) replication. One such compound inhibited WNV, with a 50% effective concentration of 0.7 μM, and reduced reporter expression from cells that harbored a WNV-based replicon. Our results demonstrate that sultam thioureas can block a postentry, preassembly step of WNV replication.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00007-07

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