Author:
Brandenburg Kenneth S.,Rodriguez Karien J.,McAnulty Jonathan F.,Murphy Christopher J.,Abbott Nicholas L.,Schurr Michael J.,Czuprynski Charles J.
Abstract
ABSTRACTBiofilm formation byPseudomonas aeruginosahas been implicated in the pathology of chronic wounds. Both thedandlisoforms of tryptophan inhibitedP. aeruginosabiofilm formation on tissue culture plates, with an equimolar ratio ofdandlisoforms producing the greatest inhibitory effect. Addition ofd-/l-tryptophan to existing biofilms inhibited further biofilm growth and caused partial biofilm disassembly. Tryptophan significantly increased swimming motility, which may be responsible in part for diminished biofilm formation byP. aeruginosa.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
63 articles.
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