Affiliation:
1. Institut de Microbiologie, Faculté des Sciences, Université Paris XI, 91-Orsay, France
Abstract
Mutants of
Escherichia coli
in which the lysine-sensitive aspartokinase is feedback-resistant are described. In these strains, as well as in the wild type, aspartic semialdehyde dehydrogenase is subject to multivalent repression by lysine, threonine, and methionine. When these amino acids were added to a culture in minimal medium, the differential rate of synthesis of the enzyme dropped to zero and remained there for about one generation.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
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