LinezolidPenetration into Bone and Joint Tissues Infected withMethicillin-ResistantStaphylococci-Reference-Cited by-同舟云学术

LinezolidPenetration into Bone and Joint Tissues Infected withMethicillin-ResistantStaphylococci

Published:2003-12 Issue:12 Volume:47 Page:3964-3966
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kutscha-Lissberg Friedrich¹,Hebler Ute¹,Muhr Gert¹,Köller Manfred¹

Affiliation:

1. Department of Surgery-Trauma Center, BG Kliniken Bergmannsheil-Universitätsklinik, Ruhr University, Bochum, Germany

Abstract

ABSTRACT Penetration of linezolid into bone and joint tissues was studied by high-performance liquid chromatography in 13 patients suffering from implant-associated infections with methicillin-resistant staphylococci. Mean concentrations of linezolid in infected tissues were greater than 10 mg/liter in a sampling time range of 35 to 124 min after administration of the preoperative dose, except in bone specimens, where they reached 3.9 ± 2.0 mg/liter.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.47.12.3964-3966.2003

Reference10 articles.

1. Batts, D. H. 2000. Linezolid—a new option for treating gram-positive infections. Oncology (Huntington)14:23-29.

2. Borner, K., E. Borner, and H. Lode. 2001. Determination of linezolid in human serum and urine by high-performance liquid chromatography. Int. J. Antimicrob. Agents18:253-258.

3. Pharmacokinetics and Tissue Penetration of Linezolid following Multiple Oral Doses

4. Haddadin, A. S., S. A. Fappiano, and P. A. Lipsett. 2002. Methicillin resistant Staphylococcus aureus (MRSA) in the intensive care unit. Postgrad. Med. J.78:385-392.

5. Lovering, A. M., J. Zhang, G. C. Bannister, B. J. Lankester, J. H. Brown, G. Narendra, and A. P. MacGowan. 2002. Penetration of linezolid into bone, fat, muscle and haematoma of patients undergoing routine hip replacement. J. Antimicrob. Chemother.50:73-77.

Cited by 106 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Chondrocyte Invasion May Be a Mechanism for Persistent Staphylococcus Aureus Infection In Vitro;Clinical Orthopaedics & Related Research;2024-04-23

2. Current Progress and Future Perspectives in Contact and Releasing-Type Antimicrobial Coatings of Orthopaedic Implants: A Systematic Review Analysis Emanated from In Vitro and In Vivo Models;Infectious Disease Reports;2024-03-26

3. Pharmacokinetic and pharmacodynamic considerations for optimizing antimicrobial therapy used to treat bone and joint infections: an evidence-based algorithmic approach;Expert Opinion on Drug Metabolism & Toxicology;2023-08-03

4. Efficacy and Safety of Different Antibiotic Therapies for Bone and Joint Infections: A Network Meta-analysis of Randomized Controlled Trials;Current Pharmaceutical Design;2023-08

5. Monitoring Salivary Concentrations of Tedizolid and Linezolid Using Rats;European Journal of Drug Metabolism and Pharmacokinetics;2023-06-27