In Vitro Activity of TD-6424 against Staphylococcus aureus-Reference-Cited by-同舟云学术

In Vitro Activity of TD-6424 against Staphylococcus aureus

Published:2003-11 Issue:11 Volume:47 Page:3602-3604
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Pace John L.¹,Krause Kevin¹,Johnston Deborah¹,Debabov Dmitri¹,Wu Terry¹,Farrington Lesley¹,Lane Cassie¹,Higgins Deborah L.¹,Christensen Burt¹,Judice J. Kevin¹,Kaniga Koné¹

Affiliation:

1. Theravance, Inc., South San Francisco, California 94080

Abstract

ABSTRACT TD-6424, a rapidly bactericidal agent with multiple mechanisms of action, is more potent in vitro and more rapidly bactericidal than currently available agents against methicillin-susceptible and methicillin-resistant Staphylococcus aureus . TD-6424 produces a postantibiotic effect with a duration of 4 to 6 h against these organisms. The results suggest potential efficacy against susceptible and resistant strains of S. aureus .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.47.11.3602-3604.2003

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