Genotypesof Pneumocystis jiroveci Isolates Obtained in Harare,Zimbabwe, and London, UnitedKingdom-Reference-Cited by-同舟云学术

Genotypesof Pneumocystis jiroveci Isolates Obtained in Harare,Zimbabwe, and London, UnitedKingdom

Published:2003-12 Issue:12 Volume:47 Page:3979-3981
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Miller Robert F.¹,Lindley Austin R.²,Ambrose Helen E.²,Malin Adam S.³,Wakefield Ann E.²

Affiliation:

1. Department of Sexually Transmitted Diseases, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, University College London, London WC1E 6AU

2. Molecular Infectious Diseases Group, Department of Paediatrics, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DU, United Kingdom

3. Department of Clinical Pharmacology, University of Zimbabwe Clinical School, Parirenyatwa Hospital, Harare, Zimbabwe

Abstract

ABSTRACT Isolates of Pneumocystis jiroveci from sulfa-exposed and nonexposed patients from London, United Kingdom, and Harare, Zimbabwe, were genotyped. At the dihydropteroate synthase (DHPS) locus, there was evidence of selection pressure from sulfa drug exposure, and reversal of DHPS genotype ratios occurred when selection pressure was absent or was removed.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.47.12.3979-3981.2003

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