Efficacyof Sulforaphane in Eradicating Helicobacter pylori in HumanGastric Xenografts Implanted in NudeMice-Reference-Cited by-同舟云学术

Efficacyof Sulforaphane in Eradicating Helicobacter pylori in HumanGastric Xenografts Implanted in NudeMice

Published:2003-12 Issue:12 Volume:47 Page:3982-3984
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Haristoy Xavier¹,Angioi-Duprez Karine²,Duprez Adrien³,Lozniewski Alain¹

Affiliation:

1. Laboratoire de Bactériologie-Virologie, UMR CNRS 75-65

2. Laboratoire de Microchirurgie Expérimentale

3. Laboratoire d'Anatomie Pathologique EMI INSERM 0014,Faculté de Médecine, Université Henri-Poincaré, Vandæuvre-les-Nancy, France

Abstract

ABSTRACT Sulforaphane, an isothiocyanate abundant in the form of its glucosinolate precursor in broccoli sprouts, has shown in vitro activity against Helicobacter pylori . We evaluated the effect of sulforaphane in vivo against this bacterium by using human gastric xenografts in nude mice. H. pylori was completely eradicated in 8 of the 11 sulforaphane-treated grafts. This result suggests that sulforaphane might be beneficial in the treatment of H. pylori -infected individuals.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.47.12.3982-3984.2003

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