Penetration of Fosfomycin into Inflammatory Lesions in Patients with Cellulitis or Diabetic Foot Syndrome-Reference-Cited by-同舟云学术

Penetration of Fosfomycin into Inflammatory Lesions in Patients with Cellulitis or Diabetic Foot Syndrome

Published:2003-01 Issue:1 Volume:47 Page:371-374
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Legat F. J.¹,Maier A.²,Dittrich P.³,Zenahlik P.¹,Kern T.¹,Nuhsbaumer S.²,Frossard M.⁴,Salmhofer W.¹,Kerl H.¹,Müller M.⁴

Affiliation:

1. Department of Dermatology

2. Department of Surgery, Division of Thoracic and Hyperbaric Surgery, Karl-Franzens-University Graz Medical School, A-8036 Graz

3. Institute of Pharmacology and Toxicology, Karl-Franzens-University Graz, A-8010 Graz

4. Department of Clinical Pharmacology, Division of Clinical Pharmacokinetics, University of Vienna Medical School, A-1090 Vienna, Austria

Abstract

ABSTRACT We investigated the distribution of the broad-spectrum antibiotic fosfomycin in infected soft tissue of patients with uncomplicated cellulitis of the lower extremities or diabetic foot infection using in vivo microdialysis. Our findings suggest that fosfomycin exhibits good and similar penetration into the fluid in the interstitial space in inflamed and noninflamed soft tissue in patients.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.47.1.371-374.2003

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5. Distribution and Antimicrobial Activity of Fosfomycin in the Interstitial Fluid of Human Soft Tissues

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