Correlation between Pyrazinamide Activity and pncA Mutations in Mycobacterium tuberculosis Isolates in Taiwan-Reference-Cited by-同舟云学术

Correlation between Pyrazinamide Activity and pncA Mutations in Mycobacterium tuberculosis Isolates in Taiwan

Published:2003-11 Issue:11 Volume:47 Page:3672-3673
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Huang Tsi-Shu¹²,Lee Susan Shin-Jung,Tu Hui-Zin¹,Huang Wen-Kuei³,Chen Yao-Shen³,Huang Chung-Kai³,Wann Shue-Ren³,Lin Hsi-Hsun³,Liu Yung-Ching¹³

Affiliation:

1. Section of Microbiology and Infectious Diseases, Kaohsiung Veterans General Hospital

2. Department of Medical Technology, Foo-Yin Institute of Technology

3. National Yang-Ming Medical College, Taipei, Taiwan

Abstract

ABSTRACT A total of 76 clinical Mycobacterium tuberculosis isolates from Taiwan were tested for pyrazinamidase activity, pyrazinamide susceptibility, and pncA mutations. Frequency of resistance to PZA rose with increases in resistance to first-line drugs. Of 17 pyrazinamide-resistant strains, 7 (3 of which had not been previously described) possessed mutations in the pncA gene.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.47.11.3672-3673.2003

Reference22 articles.

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