Affiliation:
1. Unitat
de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili,
Reus, Spain
Abstract
ABSTRACT
We
have evaluated the efficacy of voriconazole (VRC) in a murine model of
systemic infection by
Scedosporium apiospermum
. The survival
of mice treated with VRC at 5, 20, or 40 mg/kg/day was greater than
that of the control group (
P
≤ 0.0009). VRC reduced
the tissue burden in the spleen and brain (
P
< 0.001
in both organs) in comparison with that of the control
group.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
50 articles.
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