The Human Interferon-Induced MxA Protein Inhibits Early Stages of Influenza A Virus Infection by Retaining the Incoming Viral Genome in the Cytoplasm-Reference-Cited by-同舟云学术

The Human Interferon-Induced MxA Protein Inhibits Early Stages of Influenza A Virus Infection by Retaining the Incoming Viral Genome in the Cytoplasm

Published:2013-12 Issue:23 Volume:87 Page:13053-13058
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Xiao Han¹,Killip Marian J.¹,Staeheli Peter²,Randall Richard E.¹,Jackson David¹

Affiliation:

1. Biomolecular Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, United Kingdom

2. Institute for Virology, University Medical Center Freiburg, Freiburg, Germany

Abstract

ABSTRACT The induction of an interferon-induced antiviral state is a powerful cellular response against viral infection that limits viral spread. Here, we show that a preexisting antiviral state inhibits the replication of influenza A viruses in human A549 cells by preventing transport of the viral genome to the nucleus and that the interferon-induced MxA protein is necessary but not sufficient for this process. This represents a previously unreported antiviral function of MxA against influenza A virus infection.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02220-13

Reference16 articles.

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4. Human MxA Protein: An Interferon-Induced Dynamin-Like GTPase with Broad Antiviral Activity

5. Protective role of interferon-induced Mx GTPases against influenza viruses

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