Acetylation of E2 by P300 Mediates Topoisomerase Entry at the Papillomavirus Replicon-Reference-Cited by-同舟云学术

Acetylation of E2 by P300 Mediates Topoisomerase Entry at the Papillomavirus Replicon

Published:2019-04 Issue:7 Volume:93 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Thomas Yanique¹,Androphy Elliot J.¹²^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA

2. Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana, USA

Abstract

Human papillomaviruses affect an estimated 75% of the sexually active adult population in the United States, with 5.5 million new cases emerging every year. More than 200 HPV genotypes have been identified; a subset of them are linked to the development of cancers from these epithelial infections. Specific antiviral medical treatments for infected individuals are not available. This project examines the mechanisms that control viral genome replication and may allow the development of novel therapeutics.

Funder

HHS | NIH | National Cancer Institute

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02224-18

Reference33 articles.

1. Alleviation of Human Papillomavirus E2-Mediated Transcriptional Repression via Formation of a TATA Binding Protein (or TFIID)-TFIIB-RNA Polymerase II-TFIIF Preinitiation Complex

2. Papillomavirus DNA replication — From initiation to genomic instability

3. Human papillomaviruses: basic mechanisms of pathogenesis and oncogenicity