Potentiation of the Antifungal Effects of Antibiotics by Amphotericin B-Reference-Cited by-同舟云学术

Potentiation of the Antifungal Effects of Antibiotics by Amphotericin B

Published:1972-08 Issue:2 Volume:2 Page:61-65
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kwan C. N.¹,Medoff G.¹,Kobayashi G. S.¹,Schlessinger D.¹,Raskas H. J.¹

Affiliation:

1. Department of Microbiology and Divisions of Infectious Diseases and Dermatology, Department of Medicine, Washington University School of Medicine, and Institute for Molecular Virology and Department of Pathology, St. Louis University School of Medicine, St Louis, Missouri 63110

Abstract

Amphotericin B was found to potentiate the antifungal effects of mycophenolic acid glucuronide, tetracycline, and actinomycin D by increasing the penetration of these antibiotics through the fungal cytoplasmic membrane. Because the fungi were over 100 times more susceptible than animal cells to these effects of amphotericin B, these observations might have clinical application.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.2.2.61

Reference8 articles.

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2. Fishman W. H. and P. Bernfeld. 1955. Glucuronidases p. 262-267. In S. P. Colowick and N. 0. Kaplan (ed.) Methods in enzymology vol. 1. Academic Press Inc. New York.

3. The inhibition of nucleic acid synthesis by mycophenolic acid;Franklin T. J.;Biochem. J.,1969

4. Macromolecule synthesis in temperaturesensitive mutants of yeast;Hartwell L. H.;J. Bacteriol.,1967

5. Antibiotic interactions with model mem- branes. Annu;Kinsky S. C.;Rev. Pharmacol.,1970

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