Efficacy of Ceftobiprole Medocaril against Enterococcus faecalis in a Murine Urinary Tract Infection Model

Abstract

ABSTRACTWe evaluated ceftobiprole against the well-characterizedEnterococcus faecalisstrain OG1RF (with and without the β-lactamase [Bla] plasmid pBEM10) in a murine urinary tract infection (UTI) model. Ceftobiprole was equally effective for Bla+and Bla−OG1 strains, while ampicillin was moderately to markedly (depending on the inoculum) less effective against Bla+than Bla−OG1 strains. These data illustrate anin vivoeffect on ampicillin of Bla production byE. faecalisand the stability and efficacy of ceftobiprole in experimental UTI.