Comparison of Antibodies Against Different Viruses in Cerebrospinal Fluid and Serum Samples from Patients with Multiple Sclerosis-Reference-Cited by-同舟云学术

Comparison of Antibodies Against Different Viruses in Cerebrospinal Fluid and Serum Samples from Patients with Multiple Sclerosis

Published:1974-10 Issue:4 Volume:10 Page:688-694
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Norrby Erling¹²³,Link Hans¹²³,Olsson Jan-Edvin¹²³,Panelius Martin¹²³,Salmi Aimo¹²³,Vandvik Bodvar¹²³

Affiliation:

1. Department of Virology, Karolinska Institutet, School of Medicine, Stockholm, Department of Neurology, University Hospital, Linköping, Department of Neurology, University Hospital, Lund, Sweden

2. Departments of Neurology and Virology, University of Turku, Finland

3. Institute of Immunology and Rheumatology, University Hospital, Oslo, Norway

Abstract

The occurrence of a local production in the central nervous system (CNS) of antibodies against different selected viruses was analyzed by comparison of titers in serum and cerebrospinal fluid samples from groups of 50 patients with multiple sclerosis from Finland, Norway, and Sweden. Measles antibodies were determined in hemagglutination inhibition, hemolysis inhibition, and nucleocapsid complement fixation tests; mumps, parainfluenza virus type 1, and rubella virus antibodies were determined in hemagglutination inhibition tests; and herpes simplex virus type 1 antibodies were determined in passive hemagglutination tests. For reference purposes tests were also made for adenovirus antibodies in penton hemagglutination enhancement tests and poliovirus antibodies in neutralization enhancement tests. Among the 150 multiple sclerosis patients, a local production of antibodies against measles virus was found in the CNS in 57%, against rubella virus in 19%, mumps virus in 15%, herpes simplex virus type 1 in 11%, and parainfluenza virus type 1 (Sendai) in 3%. A local production in the CNS of antibodies against any of the viruses studied was found in 71% of multiple sclerosis patients. These included 48, 16, and 7% that produced antibodies to one, two, and three or more viruses, respectively.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.10.4.688-694.1974

Reference23 articles.

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